Good general health begins with good oral health

CETYLPYRIDINIUM CHLORIDE (CPC)

 
 
 

Frequency and severity of diary-based symptoms in study participants with upper respiratory infections

 

There are in vitro and in vivo studies that show CPC's virucidal and preventive activity against some viruses, including some strains of coronavirus6,7,8.

  • Highly safe antiseptic Daily use
     

  • Substantivity of 3 to 5 hours
     

  • Antiplaque

  • Broad spectrum of action:

  1. Different types of bacteria

  2. Fungi

  3. Some viruses

Popkin et al. 20176


In vitro and in vivo study on Influenza virus (virus with lipid envelope like coronavirus)
 

 

Mechanism of action: CPC alters the lipid membrane of viruses with a lipid envelope through phisicochemical interactions, causing their rupture, and therefore, inactivation of the virus.

Transmission electron microscopy (TEM) demonstrating CPC disrupts the integrity of the viral envelope and morphology of influenza virus

CONCLUSION 

CPC effectively inactivates viruses with a lipid envelope6

Group A: Control (Untreated influenza virus)

Group B and C: Influenza virus treated with 0,0050% CPC for 5 minutes.

 

  • Viral particles exposed to CPC demonstrate disrupted envelope or cavitation (arrows)of viral units.

  • The presence of negative stain inside the virions indicates membrane permeabilization.

  • The scale bar is in the lower left corner at 100 nm (A) or 50 nm (B, C).

  • We quantified the number of intact and disrupted viruses after treatment:

 

Group A: 4,5% of viruses were disrupted

Group B and C: 86% of the viruses were disrupted A B C

Mukherjee et al. 2017


Clinical trial conducted with 94 healthy volunteers and its aim was to determine if the use of CPC applied orally
could prevent infections in the upper respiratory tract
caused by influenza virus, respiratory syncytial virus, human
metapneumovirus, rhinovirus and adenovirus.

CONCLUSION 

El CPC effectively prevents infections in the upper respiratory tract caused by viruses with a lipid envelope.

cpc.protect.png

1. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al.High expression of ACE2
receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020
Feb 24;12(1):8.
2. Rabi FA, Al Zoubi MS, Kasasbeh GA, Salameh DM, Al-Nasser AD. SARS-CoV-2 and
Coronavirus Disease 2019: What We Know So Far. Pathogens. 2020 Mar 20;9(3)
3. Wölfel R. Corman VM, Guggemos W, Seilmaier M, Zange S, Müller MA, et al.
Virological assessment of hospitalized patients with COVID-2019. Nature https://-
doi.org/10.1038/s41586-020-2196-x (2020).
4. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV
and controls in dental practice. Int J Oral Sci. 2020 Mar 3;12(1):9
5. Liu Y, Yan LM, Wan L, Xiang TX, Le A, Liu JM, Peiris M, Poon LLM, Zhang W. Viral
dynamics in mild and severe cases of COVID-19. Lancet Infect Dis. 2020 Mar 19.
pii: S1473-3099(20)30232-

6. Popkin DL,ZilkaS,DimaanoM, Fujioka H, Rackley C,SalataR et al.Cetylpyridinium
chloride (CPC) exhibits potent, rapid activitygainstinfluenza viruses in
vitro and in vivo.PathogensandImmunity. 2017;2(2):253-69.
7. Mukherjee PK, Esper F, Buchheit K, Arters K, Adkins I, Ghannoum MAet al.
Randomized, double-blind, placebo-controlled clinical trial to assess the safety
and effectiveness of a novel dual-action oral topical formulation against upper
respiratory infections. BMC Infect Dis. 2017 Jan 14;17(1):74
8. Liang Shen, Junwei Niu, Chunhua Wang, Baoying Huang, Wenling Wang, Na
Zhu, Yao Deng, Huijuan Wang, Fei Ye, Shan Cen, Wenjie Tan. 2019. High-Throughput
Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses.
Journal of Virology. doi: 10.1128/JVI.00023-19 93 (12)
9. Quirynen M, Avontroodt P, Soers C, Zhao H, Pauwels M, van Steenberghe D.
Impact of tongue cleansers on microbial load and taste. J Clin Periodontol 2004;
31: 506–510.

Conclusion

  • There are in vitro and in vivo studies that show CPC's activity against some viruses, including strains of coronavirus6,7,8.

  • Mechanism: CPC alters the lipid membrane of the virus, causing it to rupture, and therefore become inactivated.

  • Consequence: CPC could have a preventive effect against infection by viruses similar to coronavirus and may help to reduce viral load in carriers of the virus.

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